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. Author manuscript; available in PMC: 2020 Dec 24.
Published in final edited form as: Cancer Cell. 2018 Apr 9;33(4):547–562. doi: 10.1016/j.ccell.2018.03.012

Figure 2. Comparison of Single Cell Technologies to Dissect Intratumoral T Cell Dysfunction.

Figure 2

Technologies that assess T cell dysfunction at the single cell level are required to describe the heterogeneity of functional states within the TME. Current single cell technologies differ in the complexity and spatial resolution they provide. Ability to provide multiparameteric information with respect to RNA and protein expression, and ability to provide spatial information are depicted for the indicated technologies. Asterisks indicate technologies that also provide TCR sequence information and may be combined with functional testing to evaluate tumor reactivity.