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. Author manuscript; available in PMC: 2021 Jan 15.
Published in final edited form as: Anesthesiology. 2017 Oct 1;127(4):645–657. doi: 10.1097/ALN.0000000000001759

Fig. 2. Opioid analgesia reduces hypnotic concentration required to achieve slow wave activity saturation.

Fig. 2

Cumulative distribution function of Ce SWAS on induction of propofol anesthesia. The introduction of opioids (and muscle relaxants) during the clinical administration (Studies 3 and 4) potentiates the hypnotic component so that less propofol is required to achieve slow wave activity saturation across participants than in the experimental study (Study 1).