Table 4.

Sensitivity analysis at different follow-up intervals. Findings are largely robust, except at shorter follow-up of one year or less.

A. For mRS 0-1
Sample size	Time since ictus	HP CNV1	HP CNV1	rs20009992
		Low Fisher grade	High Fisher grade
			OR, 95% CI, p value
907	≤ 8 years	0.5,0.2-1.4,0.194	2.6, 1.4-4.9, 0.003	NS, p = 0.359
863	≤ 6 years	0.4, 0.1-1.2,0.106	2.8, 1.5-5.4, 0.002	NS, p = 0.263
776	≤ 4 years	0.5,0.2-1.5,0.193	2.8, 1.4-5.4, 0.003	NS, p = 0.258
575	≤ 2 years	0.5,0.2-1.7,0.258	2.0, 1.1-3.4,0.100	NS, p = 0.807
349	≤ 1 year	0.5,0.1-2.4,0.367	1.6,0.5-5.1,0.415	NS, p = 0.967
204	≤ 6 months	0.2, 0.02-1.5, 0.114	0.8,0.1-4.8,0.777	NS, p = 0.929
87	≤ 3 months	NS,p = 1.0	NS,p = 1.0	NS, p= 1.0
332	3-8 years	0.4, 0.04-4.3, 0.404	4.4, 1.3-14.4, 0.014	NS, p = 0.215

B. For GOS 5
Sample size	Time since ictus	HP CNV1	HP CNV1	rs20009992
		Low Fisher grade	High Fisher grade
			OR, 95% CI, p value
907	≤ 8 years	0.3,0.1-1.0, 0.045	2.7, 1.4-5.3, 0.003	NS,p = 0.415
863	≤ 6 years	0.3,0.1-1.0, 0.047	2.8, 1.4-5.5, 0.002	NS, p = 0.472
776	≤ 4 years	0.3,0.1-1.3,0.119	2.9, 1.4-5.9, 0.003	NS,p = 0.532
575	≤ 2 years	0.3,0.1-1.4,0.132	2.8, 1.2-6.4, 0.019	NS, p = 0.627
349	≤ 1 year	0.4, 0.1-2.7,0.370	2.8,0.7-10.6, 0.128	NS, p = 0.856
204	≤ 6 months	0.09, 0.01-1.5,0.91	6.4,0.5-87,0.165	NS, p = 0.677
87	≤ 3 months	NS,p = 1.0	NS,p = 1.0	NS,p= 1.0
332	3-8 years	0.0, 0.0-0.0, 0.998	4.0, 1.1-15.1, 0.039	NS,p = 0.512

¹HP2-2 versus HP1-1, for favourable outcome

²rs2000999 G versus A, for favourable outcome