. Author manuscript; available in PMC: 2021 Jan 18.

Published in final edited form as: Mol Cell Endocrinol. 2019 Oct 7;500:110611. doi: 10.1016/j.mce.2019.110611

Table 2.

Statistical analysis results and associated gene details on 10 differentially methylated CpG sites chosen for pyrosequencing validation. ^$ denotes closest gene to the CpG of interest, *N_ and S_ denote the upstream and downstream end of the island region. P-value corresponds to linear regression analysis of the EPIC array.

Illumina ID	^$Gene	chr	p-value	Comments	Disease	Ovary	PCOS	*CpG location
cg11683966	FLJ40434	1p.32	2.09e⁻¹⁴	Pseudogene				S_Shore
cg00112465	CCDC48	3q.21	7.04e⁻¹³	Predicted gene				Island
cg18364576	FERMT2	14q.22	3.44e⁻¹⁰	Scaffold protein related to PCOS androgen receptors	Hyper-androgenemia	Yes	Yes	N_Shore
cg10821050	SHH	7q36	1.40e⁻⁰⁹	Follicle and early embryo development, signal mediator btw granulosa and theca cells	Cancer, developmental disorders	Yes		N_Shore
cg23044884	RBPMS	8p.12	1.39e⁻⁰⁸	Transcriptional regulator				S_Shelf
cg12976821	BMPR1A	10q22	1.66e⁻⁰⁸	TGF-b pathway downregulated by testosterone	Polyposis, Thyroid	Yes	Yes	5′UTR