. Author manuscript; available in PMC: 2021 Apr 1.

Published in final edited form as: Nat Cancer. 2020 Sep 28;1(10):998–1009. doi: 10.1038/s43018-020-00115-2

Table 1. Precursors for de novo fatty acid synthesis in mice.

Metabolite	CSF: Plasma ratio (control)	CSF:Plasma ratio (leukemia)
Glucose	0.22(0.13 – 0.33)	0.24 (0.16 – 0.46)
Glutamine	0.88(0.62 – 1.08)	0.90 (0.62 – 1.38)
Lactate	0.19(0.11 – 0.28)	0.19(0.12 – 0.23)
Alanine	0.20(0.14 – 0.24)	0.18(0.10 – 0.26)
Pyruvate	0.87(0.53 – 1.59)	1.05(0.59 – 2.92)

LC-MS quantification of key nutrients extracted from CSF and plasma of healthy (Control, n=8) and NSG mice and mice transplanted with the SEM cell line at clinical endpoint (n=6).