Table 1. Correlation of Adipose Tissue PRRX1 mRNA Expression with T2D Traits in rs4684847 Risk Allele Carriers.
| PRRX1 mRNA | PRRX1 mRNA | PRRX1 mRNA | |||||
|---|---|---|---|---|---|---|---|
| All | CC | CT and TT | |||||
| rs4684847 genotypes | β | p | β | p | B | p | |
| A | n = 38 | n = 20 | n = 18 | ||||
| log(BMI) | — | 1.32 | 0.05 | 1.23 | 0.19 | 1.43 | 0.23 |
| age | 1.45 | 0.03 | 1.23 | 0.19 | 1.96 | 0.09 | |
| log(TG/HDL) | — | 6.92 | 7.54 × 10−4 | 6.40 | 0.02 | 6.35 | 0.07 |
| age | 6.97 | 7.36 × 10−4 | 6.14 | 0.02 | 6.81 | 0.07 | |
| age/BMI | 4.86 | 8.3 × 10−3 | 5.00 | 0.07 | 2.64 | 0.33 | |
| log(HOMAIR) | — | 2.77 | 3.52 × 10−3 | 3.13 | 8.3 × 10−3 | 1.80 | 0.29 |
| age | 2.77 | 3.77 × 10−3 | 3.12 | 8.6 × 10−3 | 1.70 | 0.34 | |
| age/BMI | 1.41 | 0.028 | 2.1 | 4.6 × 10−3 | -0.55 | 0.63 | |
| B | n = 67 | n = 54 | n = 13 | ||||
| log(GIR) | age/BMI | -0.51 | 1.83 × 10−7 | -0.78 | 3.30 × 10−8 | -0.38 | 0.28 |
| log(FFA) | age/BMI | 0.25 | 0.014 | 0.27 | 0.015 | -0.009 | 0.99 |
Gene expression and phenotypes were measured in (A) adipose tissue from a lean/obese patient cohort (mean ± SD 24.2 ± 9.1 kg/m2), and (B) adipose tissue samples from BMI-matched obese patients (mean ± SD 43.2 ± 3.1 kg/m2) characterized by hyperinsulinemic euglycemic clamp. rs4684847 risk allele and nonrisk allele genotypes were determined by Sequenom-assay. p values and b-estimates from linear regression analysis of PRRX1 mRNA expression levels with phenotype measures are shown. BMI, body mass index; FFA, free fatty acids; GIR, glucose infusion rate of hyperinsulinemic euglycemic clamp; HDL, high density lipoprotein; HOMA-IR, homeostasis model assessment of insulin resistance; TG, triglyceride.