Skip to main content
. Author manuscript; available in PMC: 2021 Jan 22.
Published in final edited form as: Mol Pharm. 2019 Apr 29;16(6):2494–2501. doi: 10.1021/acs.molpharmaceut.9b00086

Figure 4.

Figure 4

Norfloxacin diffusion experiments across PCPG liposomal membranes. The scatterplots show representative drug uptake experiments at pH 5 and pH 7.4, respectively. Each point in the scatter plots corresponds to the measured normalized intensity difference of a liposome. The dark points are obtained at t ≈ 0, just after the liposomes encounter the drug flow. The colored points show the value at the second measurement position, after exposure to the drug for the time indicated in the panel. The gap between the black and red points for the measurement in PBS indicates norfloxacin membrane permeability. The histogram shows the distribution of all permeability measurements combined at pH 7.4 (N = 1620, 5 technical repeats). The distribution has a mean value of 4.13 ± 0.05 x 10-6 cm/s (mean ± std. error of mean) and a median value of 3.57 x 10-6 cm/s.