Table 1.

Loci associated with left-handedness after a meta-analysis of 23andMe, UKBB and IHC data

CHR	BP	SNP	Gene	EA	NEA	EAF	Z	ORa	P	Direction
1	44172458	rs34550543	ST3GAL3	T	C	0.41	6.42	1.02	1.4 × 10–10	+++
1	160398240	rs66513715	VANGL2	D	I	0.20	–5.46	0.97	4.77 × 10–8	-??
1	169112399	rs10081960	NME7	C	G	0.60	–5.93	0.98	2.96 × 10–9	- - -
2	48624007	rs4953572	FOXN2	A	G	0.66	6.70	1.02	2.11 × 10–11	+++
2	109954066	rs4676276	SH3RF3	A	C	0.52	5.72	1.02	1.06 × 10–8	+++
2	187522750	rs13006483	ITGAV	T	G	0.28	6.59	1.03	4.51 × 10–11	+++
2	210300731	rs62213410	MAP2	A	T	0.71	–11.45	0.96	2.37 × 10–30	- - -
3	18167162	rs1398651	SATB1	A	T	0.56	5.49	1.02	4.11 × 10–8	+++
3	74246260	rs201072423	CNTN3	D	I	0.51	5.53	1.02	3.17 × 10–8	+++
3	77574555	rs62251113	ROBO2	A	C	0.37	5.45	1.02	4.94 × 10–8	+++
3	158017859	rs1526194	RSRC1	T	C	0.58	–6.65	0.98	3.02 × 10–11	- - -
4	89910701	rs28658282:T	FAM13A	T	C	0.10	–6.20	0.96	5.77 × 10–10	-??
4	103188709	rs13107325	SLC39A8	T	C	0.08	7.54	1.06	4.62 × 10–14	+++
5	71890187	rs246628	LINC02056	C	G	0.41	5.72	1.02	1.06 × 10–8	+++
5	87825490	rs2194028	TMEM161B-AS1	T	C	0.34	6.59	1.02	4.52 × 10–11	+++
5	114471109	rs1422070	TRIM36	A	C	0.60	–6.65	0.98	2.85 × 10–11	- - -
6	3143866	rs35551703	BPHL	A	G	0.04	–7.04	0.94	1.93 × 10–12	- - -
6	26599509	rs45527431	ABT1	A	G	0.91	5.86	1.04	4.63 × 10–9	++?
6	30688427	rs3132584	TUBB	T	G	0.21	–10.31	0.95	6.12 × 10–25	- - -
6	127643791	rs148342778:GTA	ECHDC1	D	I	0.65	–5.68	0.97	1.32 × 10–8	-??
7	127268806	rs806188	PAX4	T	C	0.32	6.20	1.02	5.65 × 10–10	+++
8	134274226	rs2233324	NDRG1	C	G	0.16	–7.66	0.96	1.86 × 10–14	- - -
10	124992505	rs12414988	BUB3	A	G	0.21	5.46	1.02	4.75 × 10–8	+++
11	16474017	rs1000565	SOX6	A	G	0.60	5.65	1.02	1.56 × 10–8	+++
11	66173400	rs11227478	NPAS4	A	G	0.21	–6.00	0.98	1.97 × 10–9	- - -
11	77531890	rs11820337	RSF1	T	C	0.35	6.27	1.02	3.64 × 10–10	+++
11	115081563	rs9645660	CADM1	T	C	0.52	–6.51	0.98	7.43 × 10–11	- - -
12	49539892	rs11168884	TUBA1B	T	C	0.34	–6.37	0.98	1.96 × 10–10	- - -
12	100324975	rs7132513:G	ANKS1B	C	G	0.61	6.70	1.03	2.1 × 10–11	+??
13	27294638	rs9581731	WASF3	T	C	0.71	–6.05	0.98	1.49 × 10–9	- - -
14	29628115	rs8016028	AL133166.1	T	C	0.81	–6.37	0.97	1.92 × 10–10	- - -
14	48430794	rs8012503	LINC00648	C	G	0.88	5.48	1.03	4.27 × 10–8	+++
15	91423543	rs6224	FURIN	T	G	0.47	–9.39	0.97	6.16 × 10–21	- - -
16	28828834	rs62036618	ATXN2L	A	C	0.61	–7.39	0.98	1.43 × 10–13	- -?
16	69224615	rs1424114	SNTB2	T	C	0.35	–5.48	0.98	4.21 × 10–8	- - -
16	89991599	rs4550447	TUBB3	C	G	0.12	10.12	1.06	4.67 × 10–24	+++
17	43757450	rs55974014	CRHR1	A	C	0.21	–11.43	0.95	2.97 × 10–30	- - -
19	6499231	rs66479618	TUBB4A	T	C	0.20	–6.87	0.97	6.48 × 10–12	– –+
19	42439263	rs112737242	RABAC1	D	I	0.35	–7.80	0.97	6.4 × 10–15	- -?
22	23663848	rs4822384	BCR	T	G	0.39	–5.63	0.98	1.82 × 10–8	- - -
22	28628209	rs5762532	TTC28	T	C	0.59	–5.88	0.98	4.04 × 10–9	- - -

BP, base pair positions based on the GRCh37–hg19 human genome assembly; CHR, chromosome; EA, effect allele; EAF, effect allele frequency; NEA, non-effect allele; P, meta-analysis P value; Z, Z-statistic. The direction of effects is shown in the following order: 23andMe, UKBB and IHC.

^aOR corresponds to that derived from the 23andMe results. Where the SNP is missing in a cohort, a question mark is indicated in the Direction column.