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. Author manuscript; available in PMC: 2021 Jan 29.
Published in final edited form as: Science. 2008 Feb 28;319(5870):1668–72. doi: 10.1126/science.1154584

Fig. 2.

Fig. 2

Mutation in TARDBP cosegregates with disease in kindred ALS85 (A) Linkage analysis of Affymetrix 10K SNP array data demonstrated linkage to chromosome 1p36. (B) Linkage to the region containing TARDBP was confirmed using microsatellite markers. (C) The ALS85 pedigree is shown. Affected individuals are indicated by black symbols. The proband is indicated by the arrow. Unaffected individuals have open symbols. II. 1 (vertical bar) was an obligate carrier with an anecdotal history of ALS. Slashed symbols indicate deceased subjects. Gender has been omitted for confidentiality. Microsatellite markers are shown in chromosomal order with their genetic and physical locations. Genotypes for each individual are given with inferred genotypes in parentheses. The haplotype segregating with disease is indicated by the black bar. The 1009 A>G TARDBP mutation is indicated by a red “G”.