Table 2. Multivariate analysis for OS, CIR and NRM.
| Overall survival multivariate analysis |
CIR Multivariate analysis |
NRM Multivariate analysis |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| HR# | 95%CI | P | HR# | 95%CI | P | HR# | 95%CI | P | |
| IDH2 mutated | 2.14 | 1.13-4.05 | 0.02 | ||||||
| Complex karyotype and/or TP53 | 1.82 | 1.15-2.88 | 0.011 | 2.373 | 1.43-3.93 | 0.0008 | |||
| U2AF1 mutated | 1.82 | 1.10-3.02 | 0.021 | ||||||
| NRAS mutated | 1.7 | 1.07-2.72 | 0.026 | 2.221 | 1.14-4.32 | 0.019 | |||
| Remission status treated but not in CR | 1.58 | 1.16-2.15 | 0.004 | 1.56 | 0.99-2.46 | 0.056 | |||
| Donor Sex Female | 1.54 | 1.13-2.11 | 0.0068 | 1.58 | 1.06-2.35 | 0.024 | |||
| Cytogenetic risk (IPSS-R) | 1.46 | 0.95-2.26 | 0.085 | 1.56 | 1.05-2.31 | 0.029 | |||
| HCT-CI > 2 | 1.41 | 1.04-1.93 | 0.03 | 1.53 | 1.04-2.25 | 0.029 | |||
| Age > 60 | 1.32 | 0.97-1.81 | 0.081 | 1.57 | 1.05-2.33 | 0.027 | |||
| sAML | 1.89 | 1.14-3.15 | 0.014 | 0.68 | 0.45-1.01 | 0.054 | |||
| IDH1 mutated | 2.011 | 0.88-4.58 | 0.097 | ||||||
| Patient Sex Male | 1.746 | 1.04-2.94 | 0.036 | ||||||
| EZH2 mutated | 0.359 | 0.11-1.23 | 0.1 | ||||||
#
Hazard ratios greater than or less than 1 indicate an increased or decreased risk, respectively, of an event for the category listed.
Abbreviations: CIR, cumulative incidence of relapse; NRM, non-relapse mortality; HR, hazard ratio; CI, confidence interval; P, P value; CR, complete remission; IPSS-R, International Prognostic Scoring System revised; HCT-CI, hematopoietic cell transplantation comorbidity index; sAML, secondary acute myeloid leukemia.