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. Author manuscript; available in PMC: 2021 Feb 2.
Published in final edited form as: Curr Probl Pediatr Adolesc Health Care. 2019 May 22;49(5):109–116. doi: 10.1016/j.cppeds.2019.04.004

Table 2. Definitions of measures of exposure and outcome.

Study Exposure(s) Outcome(s)
Abdulrazzaq et al, (2005)
  • Aflatoxin M1 concentration in cord blood samples analyzed using HPLC

  • Low birthweight (<2500 g)

  • Neonatal jaundice (not defined)

  • Neonatal infections (not defined)

Allen et al, (1992)
  • Aflatoxin-albumin adduct levels in serum analyzed using ELISA and HPLC

  • Titers of antibodies to asexual blood stages of a cultured Gambian isolate of P. falciparum measured using indirect immunofluorescent antibody test

  • Hepatitis B surface antigen in serum using reverse passive haemagglutination

  • Titres of antibody to the hepatitis B core antigen (anti-HBc) by radioimmunoassay

  • Proliferative responses of PBMC following stimulation with purified protein derivative of Mycobacterium tuberculin (PPD), Candida albicans extract and surface antigens of the circumsporozoite protein and merozoite stages of P. falciparum.

Denning et al, (1995)
  • Aflatoxin-albumin adduct levels in serum analyzed using ELISA.

  • Urinary water-soluble AFB1 DNA and protein adducts analyzed using ELISA.

  • Death

  • Duration of fever (Temperature >38.5°C after study entry categorized as ≤7 vs > 7 days (the latter including children who died

Oyelami et al, (2007)
  • Aflatoxin levels in post-mortem lung tissue specimens analyzed using HPLC

  • Clinically diagnosed kwashiokor

Turner et al, (2003)
  • Aflatoxin-albumin adduct levels determined by ELISA

  • Mean secretory IgA (sIgA) in saliva measured by ELISA

  • Cell-mediated immunity assessed by Multitest CMI skin test for delayed type hypersensitivity reaction to tetanus, diphtheria, streptococcus, tuberculin, candida, tricophyton, and proteus antigens applied to the skin of the forearm

  • Titers of antibody to pneumococcal serotypes 1, 5, 14, and 23 antigens after administration of 23-valent pneumococcal capsular polysaccharide vaccine

  • Titers of antibody to rabies after two doses of rabies vaccine