Table 2.
Biological pathways dysregulated in Anopheles gambiae larvae after multigenerational exposure to Cd metal.
| Pathway | Pathway ID | Pathway description | Observed gene count | False discovery rate | Regulation |
|---|---|---|---|---|---|
| Pfam | PF00089 | Trypsin | 30 | 1.89E-03 | down |
| Pfam | PF00227 | Proteasome subunit | 7 | 1.89E-03 | down |
| Pfam | PF10584 | Proteasome subunit A N-terminal signature | 5 | 3.37E-03 | down |
| Pfam | PF12032 | Regulatory CLIP domain of proteinases | 7 | 7.71E-03 | down |
| Pfam | PF00379 | Insect cuticle protein | 20 | 1.44E-02 | down |
| Pfam | PF01105 | emp24/gp25 L/p24 family/GOLD | 4 | 2.78E-02 | down |
| KEGG | 190 | Oxidative phosphorylation | 21 | 2.00E-08 | down |
| KEGG | 1100 | Metabolic pathways | 58 | 3.32E-05 | down |
| KEGG | 910 | Nitrogen metabolism | 6 | 1.63E-04 | down |
| KEGG | 3050 | Proteasome | 9 | 7.43E-04 | down |
| KEGG | 1200 | Carbon metabolism | 12 | 1.72E-03 | down |
| KEGG | 10 | Glycolysis / Gluconeogenesis | 7 | 2.57E-03 | down |
| KEGG | 1120 | Microbial metabolism in diverse environments | 14 | 2.57E-03 | down |
| KEGG | 4145 | Phagosome | 9 | 2.57E-03 | down |
| KEGG | 1230 | Biosynthesis of amino acids | 9 | 2.77E-03 | down |
| KEGG | 3013 | RNA transport | 14 | 5.22E-03 | down |
| KEGG | 330 | Arginine and proline metabolism | 7 | 6.79E-03 | down |
| KEGG | 640 | Propanoate metabolism | 5 | 7.76E-03 | down |
| KEGG | 280 | Valine, leucine and isoleucine degradation | 6 | 1.43E-02 | down |
| KEGG | 270 | Cysteine and methionine metabolism | 5 | 1.45E-02 | down |