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. Author manuscript; available in PMC: 2021 Feb 9.
Published in final edited form as: Nature. 2020 Jul 29;586(7827):133–138. doi: 10.1038/s41586-020-2541-0

Fig. 1. Mutant p53 counteracts dysplasia and tumorigenesis in the proximal gut without regaining wild-type transcriptional activity.

Fig. 1

a, Immunoblot of mouse jejunal enterocytes. PP2Ac, loading control. For gel source data, see Supplementary Fig. 1. b, c, IHC of the invasion and dysplasia marker PROX1 (b) and the proliferation marker Ki67 (c) in mouse jejunum and ileum. Scale bars, 100 μm. d, p53 ChIP–seq-derived heat maps from mouse jejunal enterocytes. e, Representative images of different segments of the mouse bowel. Arrowheads indicate visible tumours. f, Tumour size (each mouse is colour-coded). Overall average of the mean values for each mouse ± s.e.m (n, number of mice), one-sided Student’s t-test. Representative data from six (a–c) or three (e) independent experiments.