Extended Data Fig. 10. Gallic acid reverses the effect of antibiotic treatment in the distal gut of CKIa Δgut p53 R172H mice.
a, b, H&E-stained sections of mouse ileum (a) and colon (b). Scale bars, 100 μm. c, IHC of Ki67 in mouse ileum and colon. Scale bars, 100 μm. d, RT–qPCR of WNT targets in mouse ileal enterocytes. Mean ± s.e.m. (n, number of mice) relative to antibiotic-treated CKIa fl/fl (normalized to 1), one-sided Student’s t-test. e, f, IHC of WNT targets in mouse ileum (e) and colon (f). Scale bars, 100 μm. Representative data from two or three independent experiments (a–c, e, f).