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. Author manuscript; available in PMC: 2021 Feb 9.
Published in final edited form as: Nature. 2020 Jul 29;586(7827):133–138. doi: 10.1038/s41586-020-2541-0

Fig. 4. Treatment with antibiotics unleashes tumour-suppressive effects of mutant p53 in the distal gut.

Fig. 4

a, b, Haemotoxylin and eosin (H&E)-stained sections (a) and IHC of Ki67 (b) in the ileum of mice that were treated with vehicle or a cocktail of antibiotics (ABX). Inserts (H&E) show a villus at high magnification, to demonstrate the grade of dysplasia. Scale bars, 100 μm. c, Quantitative PCR with reverse transcription (RT–qPCR) of WNT target genes in ileal enterocytes from mice that were treated with vehicle or antibiotics. Mean expression ± s.e.m. (n, number of mice) relative to vehicle-treated CKIa fl/fl mice (normalized to 1), one-sided Student’s t-test. Representative data from four independent experiments (a, b).