Extended Data Fig. 1. Mutant p53 counteracts dysplasia and proliferation in the proximal mouse gut.

a, IHC of p53 in the jejunum, ileum and colon of p53 ^WT and p53 ^R172H mice before and after CKIa deletion, and in CKIa ^Δgut p53 ^Δgut mice. Scale bars, 100 μm. b, H&E-stained sections of different mouse gut segments. Inserts show high-magnification images of duodenal and jejunal villi, demonstrating the grade of dysplasia. Scale bars, 100 μm. c, IHC of PROX1 and Ki67 in mouse colon. Scale bars, 100 μm. d, Jejunal crypt length. Overall average of the mean values for each mouse ± s.e.m (n, number of crypts pooled from three mice), one-way ANOVA with Tukey’s test. Representative data from six independent experiments (a–c).