Extended Data Table 2. Details of targeted drugs included in the NLMT.

BD, twice a day; OD, once a day; NOS, Not Otherwise Specified.

Treatment Arm	IMP	Route and formulation	Trial dose and schedule
A	AZD4547 FGFR inhibitor	Oral tablets (20 &80mg)	80mg BD Continuous dosing 21 day cycles
B	Vistusertib MTORC1/2 inhibitor	Oral tablets (25 mg)	125mg BD Intermittent dosing (2 continuous days in 7) 28 day cycles
C	Palbociclib CDK4/6 inhibitor	Oral capsules (75, 100 & 125 mg)	125mg OD Intermittent dosing (21 days on, 7 days off) 28 day cycles
D	Crizotinib ALK inhibitor	Oral capsules (200& 250mg)	250 mg BD Continuous dosing 21 day cycles
E	Selumetinib MEK inhibitor	Oral capsules (25 mg)	75mg BD Continuous dosing 21 day cycles
	Docetaxel chemotherapy	IV infusion over 30-60 minutes, concentrate for solution for infusion	75mg/m2 3-weekly
F	Capivasertib (AZD5363) AKT inhibitor	Oral tablets (160& 200mg)	480 mg BD Intermittent dosing (4 days on, 3 days off) 28 day cycles
G	Osimertinib EGFRM+ and T790M+ inhibitor	Oral tablets (80mg)	80 mg OD Continuous dosing 21 day cycles
H	Sitravatinib VEGFR Inhibitor	Oral capsules (40mg & 10mg)	120 mg OD Continuous dosing 21 day cycles