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. Author manuscript; available in PMC: 2021 Jul 25.
Published in final edited form as: Nat Cell Biol. 2021 Jan 25;23(2):127–135. doi: 10.1038/s41556-020-00626-1

Figure 5. Inhibition of TOR signalling reduces the accumulation of aggregates and apoptosis in RP-deficient cells.

Figure 5

(a) Wholly heterozygous RPS23R67K/+ disc expressing RhebRNAi in the anterior compartment (with ci-GAL4). The preparation was stained with anti-Ci to mark the domain of expression and anti-Dcp1 for apoptotic figures (b) Imaginal discs of the same genotype stained with anti-p62, also shown at higher magnification in b’. (c, d). Discs from RPS23R67K/+ larvae fed for 48 h with vehicle or rapamycin. (e) Apoptotic coverage (%) in RPS23R67K/+ imaginal discs from larvae fed with vehicle (black dots) of rapamycin (red dots). n = 29 discs for each condition. Error bars denote standard deviation. For statistical analysis, a two-tailed unpaired t-test was carried out. ***P = 1.41E-11. Scale bars represent 50 μm. Genotypes for each figure panel are available in Supplementary Table 1. Source data is available for this figure.