Extended Data Table 1. Participant characteristics.
Characteristics of all participants that passed quality control in the UK Biobank (UKBB) discovery and replication cohort, the UK Digital heart cohort (UKDH) used as a second replication cohort and the dilated cardiomyopathy (DCM) patients used for disease association. Measurements are depicted in mean ± standard deviation. End-systolic volume, end-diastolic volume and mass from CMR are indexed to body surface area. BP, Blood pressure; FD, fractal dimension. *: FD measurements on the subset of 307 DCM patients with cardiac magnetic resonance imaging (Fig. 4b).
| Characteristics | UKBB (discovery) | UKBB (replication) | UKDH | DCM |
|---|---|---|---|---|
| Participants | 18,096 | 6,536 | 1,129 | 510 |
| Age (years) | 55 ± 7 | 55 ± 7 | 41 ± 13 | 54 ± 15 |
| Body surface area (m2) | 1.90 ± 0.21 | 1.90 ± 0.22 | 1.85 ± 0.20 | 1.99 ± 0.28 |
| Sex (m/f) | 9402/8694 | 3378/3158 | 621/508 | 357/153 |
| Haemodynamics | ||||
| Systolic BP (mmHg) | 137 ± 18 | 136 ± 18 | 120 ± 14 | 122 ± 31 |
| Diastolic BP (mmHg) | 81 ± 10 | 82 ± 10 | 79 ± 9 | 73 ± 20 |
| Heart rate (beats/minute) | 62 ± 10 | 63 ± 11 | 62 ± 21 | 75 ± 24 |
| Cardiac output (1/min) | 5.5 ± 1.3 | 5.4 ± 1.3 | 6.0 ± 2.0 | 7.0 ± 3 |
| Left ventricular Volumetry | ||||
| Ejection fraction (%) | 59.5 ± 6.0 | 59.6 ± 6.3 | 65.3 ± 6.9 | 40 ± 17 |
| End-systolic volume (ml/m2) | 31.9 ± 8.6 | 31.6 ± 8.9 | 28.2 ± 7.9 | 79 ± 43 |
| End-diastolic volume (ml/m2) | 78.3 ± 13.9 | 77.7 ± 14.0 | 81.2 ± 14.4 | 127 ± 52 |
| Mass (g/m2) | 45.2 ± 8.5 | 44.9 ± 8.3 | 62.8 ± 15.3 | 91 ± 39 |
| Mean global ED | 1.169 ± 0.028 | 1.169 ± 0.029 | 1.215 ± 0.038 | 1.218* ± 0.075 |