Fig. 2.

130 Hz DBS induces finely-tuned gamma (FTG) oscillations in the absence of levodopa and dyskinesia. A-E. Left: time-frequency spectrograms of representative DBS blocks. The grey bar on top of the trace and the vertical dashed lines denote DBS onset and offset. The FTG feature is surrounded by a contour in each case (based on a 70th percentile threshold of a ROI, see definition in methods section and Fig. 3A). Right: Power spectral densities (PSD) during a 50-s baseline period before DBS onset, during the DBS block and during a 5-s window after DBS cessation, with the exception of case 5 (E) in whom the spectrum of a narrower region of interest (win; 20 s long) is presented. The grey horizontal line denotes the FTG threshold at 2 standard deviations above average baseline. Peaks above the threshold are considered significant (black arrowheads). This analysis was confirmed by visual inspection.