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. Author manuscript; available in PMC: 2021 Feb 19.
Published in final edited form as: Epilepsia. 2017 Mar 11;58(5):858–871. doi: 10.1111/epi.13719

Figure 2. Bicuculline-induced PDS require Cav1.3 channels.

Figure 2

A, B Suprathreshold electrical events recorded in Cav1.2DHP-/- neurons (A) or Cav1.3-/- neurons (B) after co-administration of bicuculline (10 μM) and BayK (3 μM). C-F Analysis of the area (C, D) and duration (E, F) of all suprathreshold electrical events recorded in the presence of bicuculline in Cav1.2DHP-/- neurons (C, E) or Cav1.3-/- neurons (D, F) under three conditions of LTCC activity: endogenous activity (DMSO control), potentiated (BayK, 3 μM) and inhibited (isradipine, 3 μM). The figures in the bars indicate the total number of events evaluated. All statistically significant differences are indicated by horizontal brackets. G, H Overlay of typical suprathreshold electric events recorded from Cav1.2DHP-/- neurons (G) or Cav1.3-/- neurons (H) from the experiments analysed in C to F.