Skip to main content
. Author manuscript; available in PMC: 2021 Feb 19.
Published in final edited form as: Epilepsia. 2017 Mar 11;58(5):858–871. doi: 10.1111/epi.13719

Table 1. Summary of event (PDS, SLA)-area and -duration.

B I C – P D S Cav1.2DHP-/- (n=17) Cav1.3-/- (n=18)
area (mV x ms) DMSO BayK isra DMSO BayK isra
mean 2738 3704 2191 2632 2728 2626
SEM ± 60 ± 176 ± 50 ± 50 ± 45 ± 52
duration (ms) DMSO BayK isra DMSO BayK isra
mean 135.4 178.3 122.3 125.1 130.1 129.3
SEM ± 2.4 ± 5.7 ± 2.4 ± 1.8 ± 1.7 ± 2.1
C a f f - P D S Cav1.2DHP-/- (n=11) Cav1.3-/- (n=12)
area (mV x ms) DMSO BayK isra DMSO BayK isra
mean 1282 2007 1564 805 1141 549
SEM ± 55 ± 66 ± 72 ± 22 ± 27 ±14
duration (ms) DMSO BayK isra DMSO BayK isra
mean 73.3 101.1 95.8 46.8 62.3 34.0
SEM ± 2.8 ± 2.7 ± 3.7 ± 1.5 ± 1.6 ± 1.1
B I C - S L A Cav1.2DHP-/- (n=10) Cav1.3-/- (n=10)
area (mV x ms) DMSO BayK isra DMSO BayK isra
mean 166321 160348 141143 110878 164452 76594
SEM ± 30691 ± 24451 ± 17252 ± 10659 ± 15204 ± 8168
duration (ms) DMSO BayK isra DMSO BayK isra
mean 5385 5761 5285 5940 8073 4385
SEM ± 799 ± 881 ± 478 ± 595 ± 1033 ± 416

BayK: 3 μM Bay K8644; BIC: 10 μM bicuculline; Caff: 1 mM caffeine; DMSO: 0.3% dimethyl sulfoxide; isra: 3 μM isradipine; PDS: paroxysmal depolarization shift, SEM: standard error of the mean; SLA: seizure like activity.