Table 1. Summary of event (PDS, SLA)-area and -duration.
B I C – P D S | Cav1.2DHP-/- (n=17) | Cav1.3-/- (n=18) | ||||
---|---|---|---|---|---|---|
DMSO | BayK | isra | DMSO | BayK | isra | |
mean | 2738 | 3704 | 2191 | 2632 | 2728 | 2626 |
SEM | ± 60 | ± 176 | ± 50 | ± 50 | ± 45 | ± 52 |
duration (ms) | DMSO | BayK | isra | DMSO | BayK | isra |
mean | 135.4 | 178.3 | 122.3 | 125.1 | 130.1 | 129.3 |
SEM | ± 2.4 | ± 5.7 | ± 2.4 | ± 1.8 | ± 1.7 | ± 2.1 |
C a f f - P D S | Cav1.2DHP-/- (n=11) | Cav1.3-/- (n=12) | ||||
---|---|---|---|---|---|---|
DMSO | BayK | isra | DMSO | BayK | isra | |
mean | 1282 | 2007 | 1564 | 805 | 1141 | 549 |
SEM | ± 55 | ± 66 | ± 72 | ± 22 | ± 27 | ±14 |
duration (ms) | DMSO | BayK | isra | DMSO | BayK | isra |
mean | 73.3 | 101.1 | 95.8 | 46.8 | 62.3 | 34.0 |
SEM | ± 2.8 | ± 2.7 | ± 3.7 | ± 1.5 | ± 1.6 | ± 1.1 |
B I C - S L A | Cav1.2DHP-/- (n=10) | Cav1.3-/- (n=10) | ||||
---|---|---|---|---|---|---|
DMSO | BayK | isra | DMSO | BayK | isra | |
mean | 166321 | 160348 | 141143 | 110878 | 164452 | 76594 |
SEM | ± 30691 | ± 24451 | ± 17252 | ± 10659 | ± 15204 | ± 8168 |
duration (ms) | DMSO | BayK | isra | DMSO | BayK | isra |
mean | 5385 | 5761 | 5285 | 5940 | 8073 | 4385 |
SEM | ± 799 | ± 881 | ± 478 | ± 595 | ± 1033 | ± 416 |
BayK: 3 μM Bay K8644; BIC: 10 μM bicuculline; Caff: 1 mM caffeine; DMSO: 0.3% dimethyl sulfoxide; isra: 3 μM isradipine; PDS: paroxysmal depolarization shift, SEM: standard error of the mean; SLA: seizure like activity.