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. Author manuscript; available in PMC: 2021 Apr 14.
Published in final edited form as: Nature. 2020 Oct 14;587(7833):303–308. doi: 10.1038/s41586-020-2815-6

Extended Data Figure 6. Transgenic TERRA expressed from plasmids induces telomere fragility.

Extended Data Figure 6

a, Representative examples of metaphase chromosomes stained with FISH to visualize telomeres. DNA is stained with DAPI. Fragile telomeres are indicated by white arrowheads. b, Quantification of telomere fragility. c, Quantification of telomere fragility in cells expressing PP7-15qTERRA in which expression of RNaseH1 (RNH1) and RAD51 was manipulated as indicated. For Fig. b and c, the number of metaphases scored over 3 biologically independent experiments are indicated for each condition as n.