Extended Data Table 1. Oligonucleotides used in this study.
| Primers used for Chimeric TERRA constructs | ||
|---|---|---|
| Name | Forward | Reverse |
| Amplification of PP7 stem loops | CCGCGGCCCCGAATTCTATCGATACTCGAGATCCTA | GCTGACTAGAGGATCCACACGCGTTCTCGATAATGAA |
| Amplification of TTAGGG repeats | TTAGGGTTAGGGTTAGGGTTAGGGTTAGGG | CCCTAACCCTAACCCTAACCCTAACCCTAA |
| Amplification of 15q subtelomere | GAACGCGTGTGGATCATTCTCCTCAGGTCAGACCCG | CTAACCCTAAGGATCCTAACCGTGACCCTGACCCCG |
| Amplification of Xq subtelomere | GAACGCGTGTGGATCCCGAGTTGCGTTCTCG | CTAACCCTAAGGATCGCACATGAGGAATGTGGGTG |
| Amplificiation of AAVS1 left homology arm | TGACCGGTTGCTTTCTCTGACCAGCATTC | GTGTTAACCACTGTGGGGTGGAGGGGAC |
| Amplificiation of AAVS1 right homology arm | CGGATATCACTAGGGACAGGATTGGT | GTGATATCCTGTAGGAAGGGGCAGGAGA |
| Primers used for RT-qPCR | ||
| Name | Forward | Reverse |
| 15qTERRA | CAGCGAGATTCTCCCAAGCTAAG | AACCCTAACCACATGAGCAACG |
| GAPDH | AGCCACATCGCTCAGACAC | GCCCAATACGACCAAATCC |
| TRF1 | CTTGCCAGTTGAGAACGATATACA | CATCAGGGCTGATTCCAAGG |
| TRF2 | GGGTTATGCAGTGTCTGTCGCG | CAGTGGTGTGAGCTCAGCCT |
| POT1 | CCAAGCTCTGGATCAGTATCATT | CATAGTGGTGTCCTCTCAAATAC |
| SMG1 | CCAAGCACCGTTCCAGGAACTG | CTCTCTTGCACCGCTTTCCCAG |
| UPF1 | CGCAGGGCTACATCTCCATGAG | CTCGTCACCAAGGTAACTGTCCTG |
| UPF2 | GGCTGAGTCTGCAGACACAATGC | GCAGCAAGTTGAGAGGACATGGG |
| RNaseHI | GGCCAGGCCATCCTTTAAATGTAGG | GCTTGTTCAATGGCTTTGCAGGC |
| RPA2 | GCAGGGAACTTTGGTGGGAATAGC | CCCTTCAGGTCTTGGACAAGCC |
| RAD51 | GAGGAAAGGAAGAGGGGAAACCAG | CCCACTCCATCTGCATTAATGGCG |
| 1q subtelomere | CAGCGTCGCAACTCAAATG | CCCTCACCCTCCATGAGTAATA |
| 10q subtelomere | GCATTCCTAATGCACACATGAC | TACCCGAACCTGAACCCTAA |
| 13q subtelomere | GCACTTGAACCCTGCAATACAG | CCTGCGCACCGAGATTCT |
| 15q subtelomere | AACCCTAACCACATGAGCAACG | GCTGCATTAAAGGGTCCAGT |
| siRNAs | ||
| Gene name | Catalog number | siRNA sequences |
| siControl | D-001206-13-20 | UAGCGACUAAACACAUCAA, UAAGGCUAUGAAGAGAUAC, AUGUAUUGGCCUGUAUUAG, AUGAACGUGAAUUGCUCAA |
| SiTRF1 | M-010542-02 | CAAGAUAAACCUAGUGGUA, GGUGAUCCAAAUUCUCAUA, GGAAACUGGUCUAAAAUAC, GCCAGUUGAGAACGAUAUA |
| siTRF2 | M-003546-00 | GAAGUGGACUGUAGAAGAA, GGAAGCUGCUGUCAUUAUU, GGAAUCAGCUAUCAAUGUG, GAAGACAGUACAACCAAUA |
| SiPOT1 | M-004205-01 | AGAAAGAUGUCAACAGCUA, GAGGCAAAGAAUCGAAAUA, CAGGAGUACUAGAAGCCUA, UGCAAGAUCUCCACGUUAA |
| SiSMG1 | M-005033-01 | GUGAAGAUGUUCCCUAUGA, GAGGUUAGCUGCGGAAAGA, GGUCAGACAUCCACCAGAA, UAACUUGGCUCAGCUGUAU |
| SiUPF1 | M-011763-01 | GCUCCUACCUGGUGCAGUA, UCAAGGUCCCUGAUAAUUA, GGAAGUCGACCUCCUUUGA, CAAGAUAACAUCACUGUCA |
| siUPF2 | M-012993-01 | GGAACGAGAAUUCUUAAUA, GCAUGUACCUUGUGUAGAA, GAAGAUAUUCGAUUAGGAA, GGUCUAGAGAGUUGCGAAU |
| siRNaseH1 | M-012595-00 | GCGCAGAGCCGUAUGCAAA, GAGCUAAACAAUCGGAAGA, GCCAGGCCAUCCUUUAAAU, GACAUUCAGUGGAUGCAUG |
| siRPA2 | M-017058-00 | GAUCAAUGCACACAUGGUA, CAAAAUAGAUGACAUGACA, GAGUGAAGCAGGGAACUUU, GUGGAACAGUGGAUUCGAA |
| SiRAD51 | M-003530-04 | GAAGCUAUGUUCGCCAUUA, GCAGUGAUGUCCUGGAUAA, CCAACGAUGUGAAGAAAUU, AAGCUAUGUUCGCCAUUAA |
| siBRCA2 | M-003462-01 | GAAACGGACUUGCUAUUUA, GUAAAGAAAUGCAGAAUUC, GGUAUCAGAUGCUUCAUUA. GAAGAAUGCAGGUUUAAUA |