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. Author manuscript; available in PMC: 2021 Feb 22.
Published in final edited form as: Adv Nanobiomed Res. 2020 Nov 26;1(2):2000054. doi: 10.1002/anbr.202000054

Table 1. Summary of different studies conducted with lipid-based nanocarriers combined with magnetic nanoparticles.

Nanomaterial Targeting moiety Drug In vitro model In vivo model Main finding Ref.
SLNs TMZ BBB model Improvement of the drug release after the application of an AMF Crossing of the system through the BBB model Hyperthermia [134]
SLNs Transferrin Tumor spheroids Bovine post-mortem brain Improvement of the targeting and achievement of transcytosis Increment of the temperature inside brain tissue after AMF application [135]
SLNs Magnet Nutlin BBB model Demonstration of the ability of the system to cross the BBB model [136]
NLCs Angiopep-2 Nutlin BBB model Glioma cell targeting and transcytosis through the BBB model Cell death by hyperthermia after the application of an AMF Improvement of the drug release [60]
Gd-liposomes Glucose Magnet U87MG ectopic model Improvement of the tumor targeting by the magnetic implants and the glucose moiety [137]
Liposomes DOX C6 glioma-bearing rats Reduction of the tumor size after the application of the AMF [138]
Liposomes CPP GBM-specific antibody DOX BBB model U87MG cell line Crossing of the BBB model and targeting of glioma cells Controlled drug release by temperature Suppression of U87MG cell growth [139]
Cationic liposomes Positive charge U87MG cell line Improvement of cell death after the application of AMF together with near-infrared laser [140]