SLNs |
– |
TMZ |
BBB model |
– |
Improvement of the drug release after the application of an AMF Crossing of the system through the BBB model Hyperthermia |
[134] |
SLNs |
Transferrin |
– |
Tumor spheroids |
Bovine post-mortem brain |
Improvement of the targeting and achievement of transcytosis Increment of the temperature inside brain tissue after AMF application |
[135] |
SLNs |
Magnet |
Nutlin |
BBB model |
– |
Demonstration of the ability of the system to cross the BBB model |
[136] |
NLCs |
Angiopep-2 |
Nutlin |
BBB model |
– |
Glioma cell targeting and transcytosis through the BBB model Cell death by hyperthermia after the application of an AMF Improvement of the drug release |
[60] |
Gd-liposomes |
Glucose Magnet |
– |
– |
U87MG ectopic model |
Improvement of the tumor targeting by the magnetic implants and the glucose moiety |
[137] |
Liposomes |
– |
DOX |
– |
C6 glioma-bearing rats |
Reduction of the tumor size after the application of the AMF |
[138] |
Liposomes |
CPP GBM-specific antibody |
DOX |
BBB model U87MG cell line |
– |
Crossing of the BBB model and targeting of glioma cells Controlled drug release by temperature Suppression of U87MG cell growth |
[139] |
Cationic liposomes |
Positive charge |
– |
U87MG cell line |
– |
Improvement of cell death after the application of AMF together with near-infrared laser |
[140] |