Table 1. Clinical and demographic characteristics of study participants.
Mean values for each clinical and demographic characteristic, with standard deviation (SD) in parentheses. n= 17 non-Dantu, 16 Dantu heterozygous and 13 Dantu homozygous individuals. Statistical comparison across genotypes was performed using the Kruskal-Wallis test, while pairwise comparisons between groups performed using Dunn’s test. P adj* - adjusted for age, sex and multiple comparisons with Benjamini-Hochberg FDR adjustment. *p < 0.05.
| Pairwise comparisons between genotype groups | |||||||
|---|---|---|---|---|---|---|---|
| Characteristic | non-Dantu | Dantu Heterozygote | Dantu Homozygote | P adj (Comparison across genotype groups) | P adj (non-Dantu vs. Dantu Heterozy gote) | P adj (non-Dantu vs. Dantu Homozy gote) | P adj (Dantu Heteroz ygote vs. Dantu Homozy gote) |
| Mean Age (SD; years) | 11.4 (1.6) | 11.6 (1.7) | 9.3 (4.1) | - | 0.3671 | 0.1498 | 0.1704 |
| Sex (F/M) | 5/10 | 5/9 | 5/8 | - | 0.4557 | 0.9064 | 0.5127 |
| Red blood cell count (SD; 106/μL) | 4.60 (0.36) | 4.62 (0.34) | 4.94 (0.68) | 0.286 | 0.3538 | 0.1743 | 0.1897 |
| Reticulocyte count (SD; 106/μL) | 0.02 (0.01) | 0.04 (0.01) | 0.05 (0.02) | 0.545 | 0.4451 | 0.4539 | 0.2906 |
| White blood cell count (SD; 103/μL) | 5.83 (1.46) | 5.67 (0.78) | 6.89 (2.93) | 0.643 | 0.3684 | 0.5249 | 0.407 |
| Platelet count (SD; 103/μL) | 284.06 (77.91) | 293.31 (73.91) | 346.92 (96.40) | 0.106 | 0.3112 | 0.0594 | 0.087 |
| Haematocrit (SD; %) | 37.23 (1.66) | 37.23 (2.68) | 36.22 (2.42) | 0.188 | 0.419 | 0.0959 | 0.1357 |
| Haemoglobin concentration (SD; g/dL) | 12.54 (0.54) | 12.59 (0.93) | 12.08 (1.13) | 0.168 | 0.3615 | 0.1029 | 0.1085 |
| Mean cell volume (SD; fL) | 81.32 (4.69) | 80.78 (4.67) | 74.40 (9.66) | 0.015* | 0.344 | 0.0094* | 0.0152* |
| Mean cell haemoglobin (SD; pg) | 27.38 (1.75) | 27.31 (1.83) | 24.90 (4.12) | 0.015* | 0.454 | 0.0131* | 0.0099* |
| Mean cell haemoglobin concentration (SD; g/dL) | 33.67 (0.60) | 33.81 (0.63) | 33.33 (1.51) | 0.113 | 0.2774 | 0.0986 | 0.0622 |
| Red blood cell distribution width (SD; %) | 12.83 (1.29) | 12.70 (1.13) | 13.78 (1.66) | 0.830 | 0.4987 | 0.88 | 0.4452 |