Table 2. Selected studies linking GDM with offspring allergy.
Study | Design | Cohort | Sample size | GDM criteria | Offspring age (years) | Major outcomes for GDM-exposed offspring |
---|---|---|---|---|---|---|
Kumar et al. (2009) [26] USA | Cohort | Boston Birth Cohort | 680 | Medical record | Mean (SD): 3.2 (2.3) | In term births, GDM associated with atopic dermatitis (OR: 7.2, 95% CI: 1.5-34.5), allergen sensitization (5.7, 1.2-28.0), food sensitization (8.3, 1.6-43.3) |
Martinez et al. (2020) [25] USA | Cohort | Kaiser Permanente Southern California hospitals (retrospective birth cohort) | 97,554 | Carpenter-Coustan | Median age: 7.6 | GDM requiring antidiabetic medications associated with childhood asthma (HR: 1.12, 95% CI: 1.01-1.25), adjusted for maternal asthma |
Zugna et al. (2015) [27] Italy | Meta-analysis | 11 European birth cohorts participating in the CHICOS (Developing a Child Cohort Research Strategy for Europe) project | 85,509 | Exposure: maternal diabetes | From birth to 1-2 | Maternal diabetes (regardless of type) associated with ever wheezing (pooled RR: 1.02, 95% CI: 0.98–1.06) and recurrent wheezing (1.24, 0.86–1.79) |
CI, confidence interval; GDM, gestational diabetes mellitus; HR, hazard ratio; SMD, standardised mean difference; RR, risk ratio