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. Author manuscript; available in PMC: 2021 Feb 23.
Published in final edited form as: Ann Nutr Metab. 2021 Jan 19;76 Suppl 3(Suppl 3):4–15. doi: 10.1159/000509902

Table 2. Selected studies linking GDM with offspring allergy.

Study Design Cohort Sample size GDM criteria Offspring age (years) Major outcomes for GDM-exposed offspring
Kumar et al. (2009) [26] USA Cohort Boston Birth Cohort 680 Medical record Mean (SD): 3.2 (2.3) In term births, GDM associated with atopic dermatitis (OR: 7.2, 95% CI: 1.5-34.5), allergen sensitization (5.7, 1.2-28.0), food sensitization (8.3, 1.6-43.3)
Martinez et al. (2020) [25] USA Cohort Kaiser Permanente Southern California hospitals (retrospective birth cohort) 97,554 Carpenter-Coustan Median age: 7.6 GDM requiring antidiabetic medications associated with childhood asthma (HR: 1.12, 95% CI: 1.01-1.25), adjusted for maternal asthma
Zugna et al. (2015) [27] Italy Meta-analysis 11 European birth cohorts participating in the CHICOS (Developing a Child Cohort Research Strategy for Europe) project 85,509 Exposure: maternal diabetes From birth to 1-2 Maternal diabetes (regardless of type) associated with ever wheezing (pooled RR: 1.02, 95% CI: 0.98–1.06) and recurrent wheezing (1.24, 0.86–1.79)

CI, confidence interval; GDM, gestational diabetes mellitus; HR, hazard ratio; SMD, standardised mean difference; RR, risk ratio