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. Author manuscript; available in PMC: 2021 Aug 17.
Published in final edited form as: Nature. 2021 Feb 17;590(7847):660–665. doi: 10.1038/s41586-021-03193-z

Extended Data Figure 4. ATM activity is required for loop extrusion at DSB.

Extended Data Figure 4

(a) Hi-C maps before DSB induction of a region of the chromosome 17 in Ctrl- and SCC1-depleted cells. Left panel: 100kb resolution, right panel (magnification): 25kb resolution. (b) Genomic tracks of 4C-seq before and after DSB induction in untreated or ATM inhibitor treated cells and of differential 4C-seq signal (log2 +DSB/-DSB or +DSB+ATMi/-DSB) (10kb smoothed). (c) cis interactions computed as in ED. Fig. 3h for four DSBs viewpoints across three biological experiments, in control condition or upon ATM inhibition. P value: two-sided Wilcoxon test. Center line: median; Box limits: 1st and 3rd quartiles; Whiskers: Maximum and minimum without outliers; (n=8)