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(A) For conjugation of peptide antigen (Ag), PGA is first functionalized with a pyridyldisulfide moiety followed by conjugation of the Ag to a terminal cysteine residue via a disulfide bond. (B) For conjugation of the imidazoquinoline TLR7/8 agonist IMDQ, aliphatic amine of IMDQ is conjugated to a carboxylic acid moiety of PGA through an amide bond.
