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. Author manuscript; available in PMC: 2021 Apr 28.
Published in final edited form as: Nature. 2020 Oct 28;587(7835):626–631. doi: 10.1038/s41586-020-2857-9

Extended Data Figure 8. Macrophage-specific genetic deletion or pharmacologic inhibition of GLUD1 alters only the basal inflammation and weight of muscle tissue in aged mice.

Extended Data Figure 8

a, Representative images of F4/80+ area in crural muscles of young and aged mice.

b-i, Quantification and representative images of F4/80+ area in brain (b,c), liver (d,e), lung (f,g), and skin (h,i) of aged mice (n=5 except in b for Glud1ΔMo n=4).

j-n, Body weight (j) and mass to body weight ratio of kidney (k), liver (l), spleen (m), and fat tissues (n) of aged mice upon R162 treatment (CTRL n=5; Glud1ΔMo n=6).

a-i show representative values of at least 2 independent experiments, j-n show values of 1 experiment. Unpaired two-tailed t-test was everywhere applied, ns, not significant (P>0.05). Scale bars: 50 μm (a,i); 20 μm (c,e,g). Graphs show mean ± SEM.