Extended Data Fig. 10. Mammalian lineage-specific changes between expression layers.

a-c, Number of genes with lineage-specific patterns of slower (olive) or faster (purple) evolution at the translational layer, potentially driven by stabilizing and directional selection, respectively, for brain (a), liver (b), and testis (c). Due to the lack of a biological replicate, the branch leading to human was omitted in the liver phylogeny for the transcriptional layer. d, e, Examples of individual genes with potential patterns of stabilizing (d) or directional (e) evolution. Species names with significant changes are marked by corresponding colors. Organ and species icons were previously used in ref. ²⁵.