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. Author manuscript; available in PMC: 2021 Jul 18.
Published in final edited form as: Nat Ecol Evol. 2021 Jan 18;5(3):369–378. doi: 10.1038/s41559-020-01371-2

Fig. 1. Brain methylomes reflect the vertebrate-invertebrate CG methylation boundary.

Fig. 1

a, Global brain CpG methylation, genome size, and CpG genome content across animal species. Schematic representation of established animal phylogeny on the left-hand side. Newly generated WGBS datasets marked with a blue circle, WGBS samples from non-neural tissue marked with a red circle. The Ciona intestinalis sample corresponds to muscle tissue73, and sea anemone Nematostella vectensis sample corresponds to a gastrula sample64. Genome size represents the genome assembly size. b, Proportion of CpG sites classified according to methylation levels (mC/C). Only sites with coverage ≥ 10x were considered. Silhouettes of human, platypus, octopus and honeybee obtained from phylopic.org.