Extended Data Fig. 2. CpG hypermutability is widespread in vertebrates except the lamprey.

Percentage of Single Nucleotide Variants identified from the WGBS libraries from the total number of dinucleotides in the reference genome. In pale blue are those proportions that are equal or lower than the expected (total number of SNVs / total number of dinucleotides), and in dark blue are those that are overrepresented. Note that the mouse has very few SNVs as it is a laboratory isogenic line, however it still shows a slightly higher enrichment for SNVs in CpG dinucleotides, whereas birds have very high SNV rates on CpG dinucleotides despite having intermediate levels of CpG methylation.