Fig. 5.
Transmembrane voltage (vm) maps demonstrating how the topology of a fibrosis network influences the formation of transient block. In the tight topology each fibrotic cross divides the space around it into 4 regions, whereas in the leaky topology the regions are connected diagonally, resulting in only 2 separate regions and the potential for current to leak across the fibrosis. During sinus rhythm (top row) both topologies allow an electrical wave to cross. With a premature stimulus (bottom row), 340 ms after the 1st wave, only the tight topology experiences a transient block.