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. Author manuscript; available in PMC: 2021 Mar 11.
Published in final edited form as: Nature. 2020 Dec 2;589(7840):148–153. doi: 10.1038/s41586-020-2994-1

Extended Data Fig. 5. Comparison of Ste2 to other classes of GPCRs.

Extended Data Fig. 5

Thirty-nine receptors in the active state were aligned using GESAMT74 and then prototypical members of different classes were compared with Ste2. Both GESAMT74 and TM-align73 provided similar results. In all panels, Ste2 is shown in rainbow colouration and is compared with: a, β2-adrenoceptor (Class A; PDB code 3SN6); b, glucagon-like peptide receptor 1 (Class B; PDB code 6B3J); c, GABAB receptor (Class C, PDB code 7C7Q); d, smoothened (Class F; PDB code 6D32).