Extended Data Fig. 3. Mitochondrial stress increases CBP-1-mediated histone acetylation at the loci of UPR^mt, but not UPR^ER or UPR^CYT genes.

a, Western blots of hsp-6p::gfp worms fed with control, cbp-1, atfs-1, cco-1 or mrps-5 RNAi. RNAi targeting cbp-1 occupies 25%, atfs-1, cco-1 or mrps-5 occupies 50%. b-e, Genome tracks showing the ChIP-seq analysis for H3K27Ac and H3K18Ac over the genomic loci of gpd-2 (b), hsp-3 (c), hsp-4 (d) and hsp-16.2 (e) in worms fed with control or cco-1 RNAi. The two tracks were shown with the same total count range between basal and mitochondrial stress condition for each gene. f, Summary of the distribution analysis of the 265 increased H3K18Ac/H3K27Ac peaks on the 134 UPR^mt genes (as indicated in Fig. 2d) in response to mitochondrial stress. For uncropped gel source data, see Source Extended Data Fig. 3.