Table 5.

Statistically over-represented TFBS in genes associated with the GSEC baseline and stress analysis as determined by Opossum. Results displayed where Z-score ≥5 and Fisher ≤0.01.

Transcription factor	TF class	Information contenta	Target gene hits	Background TFBS rateb	Target TFBS rateb	Z-scorec	Fisher scored
MZF1_5-13	Zn-Finger, C2H2	9.4	301	0.0222	0.0245	10.6	2.71E−07
MZF1_1-4	Zn-Finger, C2H2	8.6	377	0.0464	0.0494	10.3	2.20E−04
SP1	Zn-Finger, C2H2	9.7	290	0.02	0.022	9.9	6.78E−08
TEAD1	TEA	15.7	100	0.0029	0.0037	9.9	2.07E−04
RELA	REL	14.8	141	0.0039	0.0048	9.2	2.39E−05
GABPA	ETS	13.9	157	0.0049	0.0057	8.3	8.50E−05
REL	REL	10.5	227	0.0089	0.01	8.1	4.86E−07
CEBPA	bZIP	9.2	210	0.0118	0.013	7.8	5.60E−04
ELF5	ETS	8.7	353	0.0291	0.0307	6.6	4.05E−07
Spz1	bHLH-ZIP	11.9	166	0.0049	0.0056	6.6	1.13E−08
NR3C1	Nuclear Receptor	14.7	60	0.0023	0.0027	6.4	1.48E−03
ELK1	ETS	8.8	315	0.0201	0.0213	6.1	2.56E−07
HLF	bZIP	11.1	124	0.0048	0.0054	5.9	6.55E−03
Arnt-Ahr	bHLH	9.5	319	0.0179	0.0189	5.7	6.97E−05
GFI	Zn-Finger, C2H2	9.5	270	0.0169	0.0179	5.4	4.65E−05
RORA_1	Nuclear Receptor	13.2	197	0.006	0.0065	5.0	1.61E−09
NF-κB	REL	13.3	180	0.0057	0.0062	5.0	5.24E−07

^aThis is the specificity of the TFBS profile's position weight matrix.

^bThe number of times this TFBS was detected within the conserved non-coding regions of the background or target set of genes.

^cThe likelihood that the number of TFBS nucleotides detected for the included target genes is significant as compared with the number of TFBS nucleotides detected for the background set. Z-score is expressed in units of magnitude of the standard deviation.

^dThe probability that the number of hits vs. non-hits for the included target genes could have occurred by random chance based on the hits vs. non-hits for the background set.