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. 2016 Nov 16;1861(5):1429–1447. doi: 10.1016/j.bbagen.2016.11.027

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© 2016 Elsevier B.V. All rights reserved.

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Fig. 11 — Multifunctional aptamer AGRO100 (better known as AS1411) as a DNAzyme-based platform for the chemiluminescence detection of nucleolin expressed at the surface of HeLa cells. After the binding of hemin, the folded AGRO100 can label the cell-surface-expressed nucleolin in situ, providing an approach to sensing this protein marker in the luminol–H₂O₂ system.