Table 1.
Sample clinical trials of selected phytochemicals.
| Cancer Type | Identifier no. | Year | No. | Trial title | Intervention | Phase |
|---|---|---|---|---|---|---|
| Breast Cancer | NCT00852332 | 2009 | 100 | Docetaxel With or Without a Phytochemical in Treating Patients With Breast Cancer | Curcumin Taxotere | II |
| Colorectal Cancer | NCT01333917 | 2010 | 40 | Curcumin Biomarkers | Curcumin C3 | I |
| Colonic cancer | NCT01490996 | 2012 | 51 | Combining Curcumin With FOLFOX Chemotherapy in Patients With Inoperable Colorectal Cancer (CUFOX) | Curcumin C3 Chemotherapy |
I/II |
| Prostate cancer | NCT02095717 | 2014 | 50 | Multicenter Study Comparing Taxotere Plus Curcumin Versus Taxotere Plus Placebo Combination in First-line Treatment of Prostate Cancer Metastatic Castration Resistant (CURTAXEL) | Curcumin Taxotere | II |
| Prostate Cancer | NCT02064673 | 2014 | 600 | Adjuvant Curcumin to Assess Recurrence Free Survival in Patients Who Have Had a Radical Prostatectomy | Curcumin | III |
| Colorectal Cancer | NCT02439385 | 2015 | 44 | Avastin/FOLFIRI in Combination With Curcumin in Colorectal Cancer Patients With Unresectable Metastasis | Curcumin Avastin/FOLFIRI | II |
| Neoplasms | NCT02944578 | 2017 | 40 | Topical Curcumin for Precancer Cervical Lesions | Curcumin | II |
| Solid Tumor | NCT00098969 | 2004 | 40 | UMCC 2003-064 Resveratrol in Preventing Cancer in Healthy Participants (IRB, 2004–535) | Resveratrol | I |
| Colon Cancer | NCT00256334 | 2005 | 11 | Resveratrol for Patients With Colon Cancer | Resveratrol | I |
| Adenocarcinoma of the Colon | NCT00433576 | 2006 | 20 | Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery | Resveratrol | I |
| Breast Cancer | NCT00676793 | 2004 | 32 | A Study of the Effect of Polyphenon E (Green Tea Extract) on Breast Cancer Progression | Polyphenon E | II |
| Cervical Cancer | NCT00303823 | 2005 | 98 | Green Tea Extract in Preventing Cervical Cancer in Patients With Human Papillomavirus and Low-Grade Cervical Intraepithelial Neoplasia | Tea catechin extract | II |
| Barrett Esophagus | NCT00233935 | 2005 | 55 | Defined Green Tea Catechin Extract in Preventing Esophageal Cancer in Patients with Barrett's Esophagus | Catechin Extract | I |
| Carcinoma | NCT02029352 | 2014 | 42 | Topical Green Tea Ointment in Treatment of Superficial Skin Cancer | Sinecatechins 10% | II/III |
| Lung Neoplasms | NCT02577393 | 2015 | 53 | Study of Epigallocatechin-3-gallate (EGCG) for Esophagus Protection in Patients With Lung Cancer Receiving Radial Radiotherapy | EGCG | II |
| Colon Cancer | NCT02891538 | 2017 | 50 | Chemopreventive Effects of Epigallocatechin Gallate (EGCG) in Colorectal Cancer (CRC) Patients | EGCG | I |
| Bladder Cancer | NCT00118040 | 2005 | 60 | Phase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder Cancer | Genistein | II |
| Breast Cancer | NCT00290758 | 2006 | 126 | Genistein in Preventing Breast Cancer in Women at High Risk for Breast Cancer | Genistein | II |
| Prostate Cancer | NCT01036321 | 2009 | 71 | Phase II Clinical Trial of Purified Isoflavones in Prostate Cancer: Comparing Safety, Effectiveness | Purified isoflavones | II |
| Non-small cell lung cancer | NCT01628471 | 2012 | 20 | MTD Determination, Safety and Efficacy of the Decitabine-Genistein Drug Combination in Advanced Solid Tumors and Non-Small Cell Lung Cancer | Genistein Decitabine | I/II |
| Carcinoma | NCT02567799 | 2015 | 36 | BIO 300 Non-Small Cell Lung Cancer Study (NSCLC) | BIO300 Paclitaxel Carboplatin Radiotherapy | I/II |
From https://clinicaltrials.gov/including year started and number of participants.