Table 2.

Select cellular targets for dietary phytochemicals and repositioned drugs in cancer stem cells (CSCs).

	Phytochemicals				Drugs
	Curcumin	Resveratrol	EGCG	Genistein	Metformin	Niclosamide	Thioridazine	Chloroquine
Signaling pathway
Hedgehog	+		+	+				+
Wnt	+	+	+		+	+
Notch	+		+	+	+	+
Kinases	+	+		+	+	+	+	+
Inflammation
NFκB	+	+	+	+	+	+
IL-6	+	+
STAT 3	+	+	+	+		+		+
Epigenetics
Micro RNA	+		+		+
SIRTUIN		+			+
Drug resistance
Efflux	+		+	+				+
ALDH	+	+
Metabolism
AMPK		+	+		+		+
ROS		+		+	+	+
No Anchorage
Spheroids	+	+	+	+	+	+	+	+
EMT	+	+	+		+	+
Metastasis	+			+			+
Apoptosis	+	+		+	+	+	+	+
Autophagy	+	+			+		+	+
Differentiation	+			+	+		+	+
Drug Synergy	+		+	+	+	+	+	+

Information adapted from reviews [6, 7, 41, 52, 78, 91, 105] and additional references cited in text. A Plus sign indicates effect of the compound on a particular cellular target or pathway or process.