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Peptidase families that occur in all five eukaryote kingdoms but not in most phyla.
| Family | Type example | Kingdoms with few represented phyla |
|---|---|---|
| A28 | DNA-damage inducible protein 1 | Chromista |
| C14 | caspase | Fungi |
| C15 | pyroglutamyl-peptidase I | Fungi |
| C54 | autophagin | Fungi |
| C65 | otubain | Chromista |
| C78 | UfSP1 peptidase | Fungi |
| C86 | ataxin | Fungi, Protozoa |
| C121 | MINDY-4 peptidase | Fungi, Protozoa |
| M12 | astacin | Chromista, Protozoa |
| S28 | lysosomal Pro-Xaa carboxypeptidase | Fungi |
