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. 2019 Aug 1;166:4–18. doi: 10.1016/j.biochi.2019.07.026

Table 7.

Peptidase families present in all seven organism kingdoms.

Family Type example
C56 PfpI peptidase
M1 membrane alanyl aminopeptidase
M3 thimet oligopeptidase
M20 glutamate carboxypeptidase
M48 STE24
M67 isopeptidase Rpn11
S1 chymotrypsin
S8 subtilisin
S9 prolyl oligopeptidase
S12 d-Ala-d-Ala carboxypeptidase B
S16 endopeptidase La
S26 signal peptidase 1
S54 rhomboid
T1 proteasome

Peptidase families widely distributed amongst phyla in each kingdom are assumed to have been present in the last universal common ancestor (LUCA).