Fig. 2.

Comparison of the conserved chicken and human phospholipase A2 core modules. The GenBank accession numbers for the chicken, mouse and human sequences are provided in Table 1. The identities between full-length PLA2 sequences of the human and chicken proteins are for sPLA2-IB, 63%; sPLA2-IIA, 45%; sPLA2-IIE, 42%; sPLA2-V, 54% and sPLA2-X, 45%. Overall, the sequences show little conservation. The active-site motifs, however, are well conserved. The phospholipase consensus motif with the catalytic HD catalytic diad, CCXXHDX, is fully conserved. In addition, the calcium loop consensus sequences YGCXCGXGG is conserved in several sPLA2 sequence. We note also a conserved arrangement of Disulfides Bridge. Identical amino acids in all 5 proteins are marked with an asterisk (∗), conservative substitutions with a colon (:), and semi-conservative substitutions with a period (.).