Table 1.
Putative protein and lipid auto-antigens in EAE and/or MS.
| Antigens | Results in MS and/or EAE | References |
|---|---|---|
| Myelin basic protein | T and B cell response in EAE and MS | Einstein et al. (1962), Laatsch et al. (1962) |
| MOG | T and B cell response in EAE and MS | Lebar et al. (1986) |
| PLP | T and B cell response in EAE and MS | Tuohy et al. (1988) |
| 2′,3′-CNP | T and B cell response in EAE and MS | Määttä et al. (1998) |
| NF 155 | Antibodies recognize the extracellular domain in MS and cause axonal injury in EAE, but only in preexisting demyelinated lesions | Charles et al. (2002), Derfuss et al. (2010), Mathey et al. (2007) |
| NF 186 | Antibodies recognize the extracellular domain in MS, inhibit axonal conduction in a complement-dependent manner and cause axonal injury in EAE | Derfuss et al. (2010), Hedstrom et al. (2007), Mathey et al. (2007) |
| Neurofilament-M | Neurofilament-M-specific T cells induce severe clinical EAE with confluent demyelination and massive axonal loss | Krishnamoorthy et al. (2009) |
| Contactin-2/TAG-1 | Contactin-2/TAG-1-specific T cells induce inflammatory lesions in the cortex and white and gray matter thereby opening locally the BBB and causing occasionally clinical EAE | Derfuss et al., 2009, Derfuss et al., 2010, Mörtl et al. (2007), Shimoda and Watanabe (2009) |
| S100β | Strong T cell response in EAE | Kojima et al. (1997) |
| Phosphatidylserine | Promotion of demyelination in marmoset EAE | Ohler et al. (2004) |
| Sulfatides | T and B cell response in EAE | Kanter et al. (2006) |
| Oxidized phosphatidylcholine | Strong antibody reactivity in MS brain and EAE spinal cord | Qin et al. (2007) |
| Ganglioside GM1, sulfatide and galactosylceramide | Increased reactivity of pro-inflammatory cytokine secreting CD8+ T cells in MS patients | Shamshiev et al. (1999) |
| Gangliosides GM3 and GQ1b | Increased T cell response in primary progressive MS patients | Pender et al. (2003) |
| Ganglioside GD1a | Increased antibodies in serum and cerebrospinal fluid of patients with MS and optic neuritis | Matà et al. (1999) |
| Lactosylceramide and l-α-lysophosphatidylserine | Strong antibody reactivity in serum and cerebrospinal fluid of MS patients | Kanter et al. (2006), Quintana et al. (2008b) |