Table 2.
Susceptibility genes of MS.
| Gene | Function | References |
|---|---|---|
| HLA-DRB1*1501 | Antigen presentation | Barcellos et al. (2006), Chao et al. (2008), IMSGC (2007), Khare et al. (2005) |
| IL-2α receptor | T and B cell activation | IMSGC (2007) |
| IL-7α receptor | T cell survival, differentiation and homeostasis, B cell development | Gregory et al. (2007), IMSGC (2007) |
| EV15 | GTPase activation | Dabbeekeh et al. (2007), Hoppenbrouwers et al. (2008) |
| CD58 (lymphocyte-associated antigen 3, LFA-3) | Ligand of CD2, costimulatory molecule for T cells enhancing FoxP3 expression in Treg cells | De Jager et al. (2009a), Hoppenbrouwers et al. (2009) |
| CLEC16A (C-type lectin domain family 16, member A) | Unknown function, but highly expressed in dendritic cells, B cells and NK cells… | Hoppenbrouwers et al. (2009), Johnson et al. (2010), Rubio et al. (2008) |
| CD6 | ||
| Bacterial molecular pattern recognition and suppressing TNF-α, IL-6 and IL-1β | De Jager et al. (2009b), Sarrias et al. (2007) | |
| IRF8 (IFN regulatory factor 8) | Activation or repressing of IFN type I transcription | De Jager et al. (2009b), Johnson et al. (2010) |
| TNFRSF1A (tumor necrosis factor receptor superfamily, member 1A) | Pro-inflammatory and proapoptotic activity | De Jager et al. (2009b) |
| OLIG3-TNFAIP3 (oligodendrocyte transcription factor 3—NF-α-induced protein 3) | Development of neuronal cells, tumor suppression and anti-inflammation | De Jager et al. (2009b) |
| IL-12A (IL-12p35) | Growth factor for activated T and NK cells, enhancing the lytic activity of NK/lymphokine-activated killer cells | Rubio et al. (2008) |
| PTGER4 (prostaglandin E receptor 4) | Activation of T cell factor signaling | De Jager et al. (2009b) |
| RGS1 (regulator of G-protein signaling 1) | B cell activation | Johnson et al. (2010) |
| TYK-2 (tyrosine kinase 2) | Intracellular signal transduction of type I IFNs | Johnson et al. (2010), Mero et al. (2010) |
| CD226 | Intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T cells and NK cells | Hafler et al. (2009) |
| KIF1B (kinesin family member 1B) | Motor protein transporting mitochondria and synaptic vesicle precursors | Aulchenko et al. (2008) |
| RPL5 (ribosomal protein L5) | Transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. | Rubio et al. (2008) |