Table 4: Correlation Between Changes in DNA Methylation and RNA Expression in Genes Related to Glutamate Signaling.

Fold changes and their respective p-values (RNA column) are listed for each endocrine group comparison. DM column at what endocrine status differential cytosine methylation was observed, within what region (promoter, exon, or intron), and whether the site(s) were hypo-, strongly(S) hypo, hyper-, or strongly hyper-methylated. Hyper- or hypo-methylated is defined as 0-33% more, or less respectively, methylated than reference (p-value < 0.05). Strongly hyper- or strongly hypo-methylated is defined as 33-100% more, or less respectively, methylated than reference (p-value < 0.05).

	Reg 6m – Reg 9m				Reg 9m – Irreg 9m				Irreg 9m – Acyc 9m
Gene Symbol	RNA		DM		RNA		DM		RNA		DM
GRIA1	−1.2	(0.0035)	-		-		(2) Intron	S HYPER	-		-
GRIA3	−1.1	(0.0430)	-		-		-		-		-
GRIA4	−1.3	(0.0001)	-		-		-		-		(1) Promoter	HYPER
Grid1	−1.1	(0.0331)	-		-		(6) Intron	(5) HYPO (1) HYPER	-		(6) Intron	(3) HYPO (3) HYPER
GRID2	−1.2	(0.0323)	(2) Intron	HYPER	-		(4) Intron	(3) HYPO (1) HYPER	-		(2) Intron	(1) HYPO (1) HYPER
GRID2IP	−1.6	(0.0002)	-		-		(1) Exon	HYPO	-
GRIK1	−1.2	(0.0071)	(1) Intron (1) Exon	HYPER	-		(1) Intron	HYPER	-		(1) Intron	HYPO
GRIK3	-		(4) Intron	(2) HYPO (2) HYPER	-		(4) Intron	HYPER	−1.2	(0.0432)	(2) Intron	HYPO
GRIN2A	−1.7	(0.0001)	-		-		(1) Intron	HYPO	−1.3	(0.0361)	(2) Intron	(1) HYPO (1) HYPER
GRIN2B	−1.2	(0.0035)	(6) Intron	(4) HYPO (1) HYPER (1) S HYPER	-		-		-		-
GRIN2D	−1.2	(0.0060)	-		1.1	(0.0192)	-		−1.2	(0.0222)	-
GRIN3A	−1.3	(0.0007)	-		-		-		-		-
GRM1	−1.2	(0.0003)	-		-		-		-		(1) Intron	HYPER
GRM3	−1.2	(0.0058)	-		-		-		-		(1) Intron	HYPO
GRM5	−1.2	(0.0086)	-		-		-		-		(1) Promoter	HYPER
GRM7	−1.2	(0.0082)	-		-		(3) Intron	(1) S HYPO (2) HYPO	-		(1) Intron	HYPO
VGLUT1	−3	(0.0095)	-		-		-		-		-
VGLUT3	−1.4	(0.0236)	(1) Promoter	HYPO	-		-		-		-
GLT1	−1.2	(0.0006)	(2) Intron	(1) HYPO (1) HYPER	-		-		-		-
NAT2	−1.2	(0.0011)	-		-		-		-		(1) Intron	HYPER