Table 8: Correlation Between Changes in DNA Methylation and RNA Expression in Genes Related to One Carbon Metabolism.

Fold changes and their respective p-values (RNA column) are listed for each endocrine group comparison. DM column at what endocrine status differential cytosine methylation was observed, within what region (promoter, exon, or intron), and whether the site(s) were hypo- or hyper-methylated. Hyper- or hypo-methylated is defined as 0-33% more, or less respectively, methylated than reference (p-value < 0.05).

	Reg 6m – Reg 9m				Reg 9m – Irreg 9m				Irreg 9m – Acyc 9m
Gene Symbol	RNA		DM		RNA		DM		RNA		DM
MTHFR		-	-		-		-		−1.2	(0.0481)	-
SLC44A2	1.1	(0.0314)	-		-		(1) Intron	HYPO		-	(1) Intron	HYPER
FOLR2	2.5	(0.003)	-		-		(1) Intron	HYPO		-	(1) Intron	HYPER
TYMS	−1.4	(0.0067)	-		-		-			-	-
MUT	−1.1	(0.0462)	-		-		-			-	-
PLD1	1.2	(0.0144)	-		-		(2) Intron	HYPO		-	(2) Intron	HYPER
PLD2	1.2	(0.00605)	-		-		-			-	(1) Exon (1) Intron	(1) HYPO (1) HYPER
PLD4	1.2	(0.0273)	-		-		-			-	-
NAPEPLD	−1.3	(0.0252)	-		-		-			-	-