Table 3.
Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of LAMP methods in comparison with microscopy and real-time PCR.
| Reference Method | Method | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | Kappa (κ) |
|---|---|---|---|---|---|---|
| Microscopy | Poon et al.’s LAMP | 96.2% (90.6–99.0) | 98.1% (93.3–99.8) | 98.1% (93.2–99.8) | 96.3% (90.7–99.0) | 0.94 |
| New LAMP | 99.1% (94.9–100.0) | 99.0% (94.8–100.0) | 99.1% (94.9–100.0) | 99.0% (94.8–100.0) | 0.98 | |
| Real time PCR | Poon et al.’s LAMP | 95.4% (89.5–98.5) | 99.0% (94.7–100.0) | 99.0% (94.8–100.0) | 95.3% (89.4–98.5) | 0.94 |
| New LAMP | 98.1% (93.5 –99.8) | 100.0% (96.5–100.0) | 100.0% (96.6–100.0) | 98.1% (93.3–99.8) | 0.98 | |