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(A) Results of blood, urine and kidney cultures after challenge of puppies with L. interrogans serovar canicola. Puppies were challenged 2 weeks after a primary course of two doses of vaccine (study 1: onset of immunity). (B) Results of blood, urine and kidney cultures after challenge of puppies with L. interrogans serovar icterohaemorrhagiae. Puppies were challenged 2 weeks after a primary course of two doses of vaccine (study 2: onset of immunity).
