Table 3.
Incidence of moderate to severe disease after challenge.
| Study | Group | Disease incidence (no. of dogs) |
P-value* | |
|---|---|---|---|---|
| No to mild | Moderate to severea | |||
| 1 | V | 9 | 0 | 0.00004 |
| C | 0 | 8 (4) | ||
| 2 | V | 9 | 0 | 0.0077 |
| C | 4 | 6 (6) | ||
| 3 | V | 7 | 0 | 0.0186 |
| C | 3 | 5 (1) | ||
| 4 | V | 9 | 0 | 0.124 |
| C | 7 | 3 (3) | ||
Abbreviations: V = vaccinated; C = control. Study 1 = onset of immunity L. interrogans serovar canicola; study 2 = onset of immunity L. interrogans serovar icterohaemorrhagiae; study 3 = duration of immunity L. interrogans serovar canicola; study 4 = duration of immunity L. interrogans serovar icterohaemorrhagiae.
a
In brackets the number of dogs that died or had to be euthanised after challenge.
*
Fisher's exact test.